Hop bitterness in beer evaluated by computational analysis

نویسندگان

چکیده

Beer flavour and aroma are greatly influenced by the hop(s) employed in brewing process. The iso-α-acids post wort boiling major compounds responsible for bitterness, which detected bitter taste receptors (TAS2Rs) oral buds. This family of is activated presence molecules, send chemical signals to brain, making it possible differentiate whether molecules have a pleasant (or not). It interest predict behaviour hop towards such that bitterness different varieties can be predicted based on quantitative analysis composition. Computational simulation, high-performance computing (HPC), allow simulation interactions with various TAS2Rs, enabling prediction these compounds. These techniques, will soon enable design beverages customised flavours, reducing need experimental evaluation. In this work, α β-acids, iso-α-acids, prenylflavonoids analysed against TAS2R10, TAS2R14 TAS2R46. Using computational blind docking molecular dynamics, xanthohumol was identified highest profile.

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ژورنال

عنوان ژورنال: Journal of The Institute of Brewing

سال: 2023

ISSN: ['0046-9750', '2050-0416']

DOI: https://doi.org/10.58430/jib.v129i2.20